FREQUENCY OF SICKLE CELL DISEASE AMONG ALHASSANIA TRIBE IN THE WHITE NILE STATE, SUDAN

  • 1AhlamA. Hmed 2*Mahdi H. A. Abdalla 1 Faculty of Medical Laboratory Sciences, Alneelain University, Sudan 2 Department of Haematology, Faculty of Medical Laboratory Sciences, Omdurman Ahlia University, Sudan

Abstract

Sickle cell anemia (SCA) is a hereditary blood disorder (autosomal recessive), characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells' flexibility and results in a risk of various life-threatening complications.Two hundred and fifty subjects were randomly selected and enrolled in this cross-sectional study, from general population of Alhassania tribe who are live in the White Nile state in Sudan, Two ml of venous blood was collected in EDTA anticoagulant from each subject for haematological analysis and haemoglobin electrophoresis.4.8% of the study population has an abnormal haemoglobin variants, the haemoglobin electrophoresis showed HbSS with 2%,  HbAS with 2.8% and HbAA with 95.2% frequency, no other abnormal Hb variant was detected . All patients with Hb SS are severely anaemic with maximum Hb level of 7.4 g/dl; and 80% of them have leukocytosis with TWBC count higher than 11.0X109/L. In conclusion, our study reported low frequency of Hb S among Alhassania tribe in the White Nile state in comparison with previous reports in Sudan, in particular those from western Sudan.

Key words: Hb S, Alhassania tribe, Sudan.

Published
2017-10-30
How to Cite
Abdalla1. H. 2. H. A. (2017). FREQUENCY OF SICKLE CELL DISEASE AMONG ALHASSANIA TRIBE IN THE WHITE NILE STATE, SUDAN. Journal of Biomedical and Pharmaceutical Research, 4(3). Retrieved from http://www.jbpr.in/index.php/jbpr/article/view/189
Issue
Vol. 4 No. 3 (2015)
Section
Research Articles

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