STUDY ON MATRIX METALLOPROTEINASES IN DIABETIC FOOT ULCER DISEASE

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Julie Susan Sam* Baskaran Krishnan

Abstract

The aim of this study is to compare the level of matrix metalloproteinases in diabetic and non-diabetic foot ulcer disease patient’s plasma and tissue sample. Design: Cross-sectional study. Patients: We studied a group of adults with T2DM (n=10) and another group of adults without T2DM (n=6). Measurements: MMPs in plasma and tissue samples were detected by gelatin zymography. Results: The plasma and tissue concentrations of MMP-9 and MMP-2 and non-enzymatic antioxidants were found to be increased in diabetic foot ulcer patients compared to non-diabetic foot ulcer patients. Conclusion: The elevated levels of MMP-9 and -2 in chronic ulcer subjects, delays wound healing process by degrading the extracellular matrix materials in an uncontrolled way. This study provides evidence for the role of MMPs 2 and 9 in diabetic foot ulcer disease.


Key words: Matrix metalloproteinases, gelatin zymography, diabetic foot ulcer

Article Details

How to Cite
Krishnan, J. S. S. (2017). STUDY ON MATRIX METALLOPROTEINASES IN DIABETIC FOOT ULCER DISEASE. Journal of Biomedical and Pharmaceutical Research, 4(3). Retrieved from http://www.jbpr.in/index.php/jbpr/article/view/199
Section
Research Articles