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The aim of this study is to compare the level of matrix metalloproteinases in diabetic and non-diabetic foot ulcer disease patient’s plasma and tissue sample. Design: Cross-sectional study. Patients: We studied a group of adults with T2DM (n=10) and another group of adults without T2DM (n=6). Measurements: MMPs in plasma and tissue samples were detected by gelatin zymography. Results: The plasma and tissue concentrations of MMP-9 and MMP-2 and non-enzymatic antioxidants were found to be increased in diabetic foot ulcer patients compared to non-diabetic foot ulcer patients. Conclusion: The elevated levels of MMP-9 and -2 in chronic ulcer subjects, delays wound healing process by degrading the extracellular matrix materials in an uncontrolled way. This study provides evidence for the role of MMPs 2 and 9 in diabetic foot ulcer disease.
Key words: Matrix metalloproteinases, gelatin zymography, diabetic foot ulcer
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