Evaluation of Brain Targeting of Drugs after Administered Intranasally

Abstract

Intranasal route has potential to target brain and possesses several advantages over parenteral and oral routes in treating CNS disorders such as stroke, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, epilepsy and psychiatric disorders. Nasal drug delivery is attracting attention of many researchers to develop efficient drug delivery systems to target brain using novel drug delivery systems. A number of in-vivo, ex-vivo and in-vitro methods have been used to study and evaluate nose-to-brain drug delivery system. The present review discusses the currently available methods to evaluate brain uptake of drug after intranasal administration. 

KEY WORDS: Intranasal, Olfactory, in vivo-ex vivo evaluation.