FUNCTIONAL ROLES OF LIPID METABOLITE CDP DIACYLGLYCEROL AND ITS SYNTHASE ENZYMES: RECENT DEVELOPMENTS

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Manoj G Tyagi Dharmendra Singh Nirmala Joyce Mohammed Amil Shyam S Yadav

Abstract

Phospholipids are basic building-block molecules for biological membranes. Biosynthesis of phospholipids i.e phosphatidylinositol, phosphatidylglycerol and phosphatidylserine requires a central liponucleotide intermediate named cytidine-diphosphate diacylglycerol (CDP-DAG). The CDP-DAG synthase (CDS) is an integral membrane enzyme catalysing the formation of CDP-DAG, an essential step for phosphoinositide recycling during signal transduction. New roles are being ascribed to the CDP-DAG in signalling and pathophysiological conditions. This pathway may also be the target of novel drugs to be used in neuro-psychiatric conditions.


Key words: Phospholipids, Cytidine diphosphate, diacylglycerol, phosphatidic acid, phosphatidylglycerol.

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How to Cite
Tyagi, M., Singh, D., Joyce, N., Amil, M., & Yadav, S. S. (2019). FUNCTIONAL ROLES OF LIPID METABOLITE CDP DIACYLGLYCEROL AND ITS SYNTHASE ENZYMES: RECENT DEVELOPMENTS. Journal of Biomedical and Pharmaceutical Research, 8(1). https://doi.org/https://doi.org/10.32553/jbpr.v8i1.572
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Research Articles