Journal of Biomedical and Pharmaceutical Research <p><img src="/public/site/images/adminjbpr/jbpr.in_.jpg"></p> <p>&nbsp; &nbsp;</p> <p>&nbsp; &nbsp; &nbsp;&nbsp;<a title="|| Pub-Med NLM ID (URL) ||" href="" target="_blank" rel="alternate noopener noreferrer">|| Pub-Med NLM ID (URL) ||</a>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; ||&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<a href="" target="_blank" rel="alternate noopener noreferrer">|| Index Copernicus (URL) ||</a></p> <p>&nbsp;</p> <p>Journal of Biomedical and Pharmaceutical Research (JBPR) is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</p> <p><strong>Medical || Dentistry || Biomedical Sciences:</strong></p> <p>Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology,&nbsp;Histopathology, Toxicology and all major disciplines of Biomedical Sciences.<br><strong>Pharmaceutical Sciences || Allied Sciences&nbsp;</strong></p> <p>Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical&nbsp; Sciences.</p> <p>Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</p> <p><strong>Top Reasons for publication with us</strong></p> <p><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</p> <p><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. JPBR only charge the fees necessary to recoup cost associated with running the journal</p> <p><strong>Other features:</strong> DIDS Assigned and Implemented the Open Review System (ORS).</p> <p><strong>Important Notice:</strong></p> <p>Author can now directly send their manuscript as an email attachment to</p> <p>Innovative Library</p> <p><strong></strong>, <strong></strong></p> <p>&nbsp;</p> en-US <p><a href="" rel="license"><img style="border-width: 0;" src="" alt="Creative Commons License" width="60" height="21" border="0"></a><span style="line-height: 1.3em;">Journal of Biomedical and Pharmaceutical Research&nbsp;</span><span style="line-height: 1.3em;">by </span><span style="line-height: 1.3em;">Articles</span><span style="line-height: 1.3em;"> is licensed under a </span><a style="line-height: 1.3em;" title="Journal of Biomedical and Pharmaceutical Research" href="" target="_blank" rel="license noopener">Creative Commons Attribution 4.0 International License</a><span style="line-height: 1.3em;">.</span></p> (Innovative Library) (Priyanka Gupta) Tue, 06 Mar 2018 00:00:00 +0000 OJS 60 Formulation and In-vitro Evaluation of Fast Disintegrating Tablet of Eprosartan Mesylate <p>In the present work, fast dissolving tablets of Eprosartan Melysate were prepared by direct compression method with a view to enhance patient compliance. One super-disintegrants, viz., crospovidone use in different ratios with microcrystalline cellulose along with directly compressible mannitol to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and&nbsp;<em>in vitro</em>&nbsp;dispersion time. Based on&nbsp;<em>in vitro</em>&nbsp;dispersion time (approximately 13s), nine formulations batches were tested for the&nbsp;<em>in vitro</em>&nbsp;drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40°/75% relative humidity for 6 month) and drug-excipient interaction (IR spectroscopy). Among the nine promising formulations, the formulation prepared by using 10% w/w of crospovidone and 35% w/w of microcrystalline cellulose emerged as the overall best formulation (t<sub>50%</sub>&nbsp;1.8 min) based on the&nbsp;<em>in vitro</em>&nbsp;drug release characteristics compared to conventional commercial tablet formulation (t<sub>50%</sub>&nbsp;16.4 min). Short-term stability studies on the formulations indicated that there were no significant changes in drug content and&nbsp;<em>in vitro</em>&nbsp;dispersion time.</p> <p><strong>Keywords:&nbsp;</strong>Fast dissolving tablets, Eprosartan melysate , Crospovidone, Microcrystaline cellulose</p> S.B. Humane, D.N. Shinkar, R . B. Saudagar ##submission.copyrightStatement## Tue, 06 Mar 2018 00:00:00 +0000 AQUASOMES: An Overview <p>Aquasomes are one of the most recently developed delivery system for bioactive molecules like peptide, protein, hormones, antigens and genes to specific sites. Aquasomes are spherical in shape with 60300 nm particles size. Aquasomes are spherical particles composed of calcium phosphate or ceramic diamond covered with apolyhydroxyloligomeric film and act as nanoparticulate carrier system but instead of being simple nanoparticle these are three layered self-assembled structures, comprised of a solid phase nanocrystalline core coated with oligomeric film on which biochemically active molecules are adsorbed with or without modification. It is widely used for the preparation of implants. Aquasomes exploited as a RBC substitutes, vaccines for delivery of viral antigen and as targeted system for intracellular gene therapy. Enzyme activity and sensitivity towards molecular conformation made aquasome as a novel carrier for enzymes like&nbsp;&nbsp; DNAses and pigment/dyes. This report reviews the principles of self assembly, the challenges of maintaining both the conformational integrity and biochemical activity of immobilized Surface&nbsp; pairs. The delivery system has been successfully utilized for the delivery of insulin, haemoglobin, and enzymes like serratiopeptidase etc.</p> <p>&nbsp;</p> Priya Gupta ##submission.copyrightStatement## Tue, 06 Mar 2018 00:00:00 +0000