IMMUNOHISTOCHEMICAL CORRELATION OF E-CADHERIN EXPRESSION WITH DIFFERENTIATION GRADE OF INVASIVE DUCTAL CARCINOMA IN SUDANESE FEMALES

Abstract

Background: E-cadherin is a cell surface protein involved in cell adhesion, present in normal breast epithelium, and in certain breast carcinoma. The utility of the E-cadherin immunohistochemical stain to distinguish between lobular and ductal carcinomas that are difficult to classify by morphologic features alone has been well-documented.
Objectives: this study aimed to investigate E-Cadherin expression in invasive ductal carcinoma of different grades of differentiation and correlated the expression patterns with their histological type and grade using immunohistochemical staining.
Materials and methods: Formalin fixed-Paraffin embedded blocks from 50 female patients with invasive ductal carcinoma were used, immunohistochemistry staining for E-cadherin was performed and the intensity and extension of E-Cadherin immunoreactivity was evaluated as normal or loss of expression in all 50 cases of different grades invasive ductal carcinoma and correlated with their histological type and grade.
Results: 72% of cases showed normal expression of E-cadherin and 28% had loss of expression, we found that loss of expression of E-cadherin increase with increase of tumor grade from 2% for Grade 1 to 16% in Grade 3 tumor. But statistical analysis showed no significant association p value (0.920).
Conclusion: we conclude that there is no statistical significant Loss of E.cadherin expression in invasive ductal carcinoma grades in Sudanese patients.