Urokinase and its receptor uPAR is a critical component of pulmonary renal cascade and is significant for pulmonary function and contributes to the physiological regulation; relationship with Serpin E2

  • Manoj G Tyagi Department of Pharmacology, KM Medical College, Mathura, Uttar Pradesh
  • Vikram GS India and Vellore Institute of Technology, Vellore, Tamilnadu
  • Vishakha Tyagi India and Vellore Institute of Technology+, Vellore, Tamilnadu
  • Dharmendra Singh India and Vellore Institute of Technology, Vellore, Tamilnadu
  • S Thirumalai Velu India and Vellore Institute of Technology+, Vellore, Tamilnadu
DOI: https://doi.org/10.32553/jbpr.v8i3.627
Keywords: Urokinase, suPAR, lungs, SERPIN, physiological, airways

Abstract

Many previous studies have shown that induction of uPA, uPA receptor (uPAR), and PAI-1 may occur in lung endothelial cells (ECs) through a uPA-mediated feedback pathway. Soluble urokinase-type plasminogen activator receptor (suPAR) is a soluble form of the urokinase plasminogen activator receptor (uPAR) that is produced upon cleavage of membrane-bound uPAR. It is found in various body fluids, including blood, urine and cerebrospinal fluid. It is now known that Pulmonary function in physiological and patho-physiological condition is regulated by these molecules. On the other hand, Protease nexin-1 or serine protease inhibitor (Serpin E2) is intricately linked in the physiological homeostasis and interacts with uPA system. These are the key elements of the pulmonary renal cascade regulating multiple physiological functions.

Key words: Urokinase, suPAR, lungs, SERPIN, physiological, airways

Published
2019-06-28
How to Cite
Tyagi, M. G., GS, V., Tyagi, V., Singh, D., & Velu, S. T. (2019). Urokinase and its receptor uPAR is a critical component of pulmonary renal cascade and is significant for pulmonary function and contributes to the physiological regulation; relationship with Serpin E2. Journal of Biomedical and Pharmaceutical Research, 8(3), 156-160. https://doi.org/10.32553/jbpr.v8i3.627
Issue
Vol. 8 No. 3 (2019)
Section
Review Articles

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