Design, Development and Evaluation of Aceclofenac Matrix Tablet Using Eudragit and Carbopol as Matrix Forming Agents

  • Arindam Chatterjee Associate Professor, Jaipur College of Pharmacy, Jaipur, Rajasthan, India
  • Alok M Patel Plant Head, Sunrise Remedies Pvt. Ltd. Santej Teh Kalol Dist. Gandhi Nagar, Gujarat
  • Rakesh Kumar Gupta Professor, Jaipur College of Pharmacy, Jaipur, Rajasthan, India
  • Anuj Mishra Research Scholar, Jaipur College of Pharmacy, Jaipur, Rajasthan, India
DOI: https://doi.org/10.32553/jbpr.v11i2.907
Keywords: Aceclofenac, Matrix Tablets, Eudragit, Carbopol, Sustained Release.

Abstract

Aceclofenac is a non-steroidal anti-inflammatory, analgesic and antipyretic agent. It has short biological half-life (4 hours). The present study aims to formulate sustained release Matrix tablet of Aceclofenac for improved patient compliance, better therapeutic efficacy, less side effects and reduced dosage regimen with less toxicity. Total six formulations (F1-F6) were prepared with varying ratios of Eudragit RS100 and Carbopol 934P as matrix forming agents and evaluated for various pre-compression and post compression parameters. Formulation (F3) containing 1:1 ratio of Eudragit RS100 and Carbopol 934P showed promising results in dissolution studies when compared to the rest of the formulations.

Keywords: Aceclofenac, Matrix Tablets, Eudragit, Carbopol, Sustained Release.

Published
2022-04-29
How to Cite
Chatterjee, A., Patel, A. M., Gupta, R. K., & Mishra, A. (2022). Design, Development and Evaluation of Aceclofenac Matrix Tablet Using Eudragit and Carbopol as Matrix Forming Agents. Journal of Biomedical and Pharmaceutical Research, 11(2). https://doi.org/10.32553/jbpr.v11i2.907
Issue
Vol. 11 No. 2 (2022)
Section
Articles

Copyright (c) 2022 Journal of Biomedical and Pharmaceutical Research

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons LicenseJournal of Biomedical and Pharmaceutical Research by Articles is licensed under a Creative Commons Attribution 4.0 International License.