Enan K.M3, Yasin M. E1, Elkhidir I.M4, Gandour M.A1, Abdelhaleem A.A2**,, 1Department of Microbiology Faculty of Medical Laboratory Sciences Alneelain University Khartoum/Sudan. 2Department of Immunology and Molecular biology Medical Research Center University of Jazan KSA. 3Department of Virology, Central Laboratory, Ministry of Science and Technology Khartoum, Sudan. 4Denepartmt of Microbiology and Parasitology, Faculty of Medicine, University of Khartoum/Sudan., Sudan