Ikhlas A. Khan1, 3Md. K. Ashfaq*,1, Ibrahim Ghalib Saleh1, 2, Zulfiqar Ali 1 Naohito Abe 1, Mohamed F. Abd-Ellah2,, 1National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA. 2Departments of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt. 3Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677, USA. *Thad Cochran Research Center, School of Pharmacy, University of Mississippi, Room 2047, University, MS 38677, USA., United Kingdom