Harpal Singh3, Annu Maheshwari4*1, Ruchika Nandha*1, Kamlesh Garg2,, *1Assistant Professor, Department of Pharmacology, Dr Harvansh Singh Judge Institute of Dental Sciences, Panjab University, Chandigarh , India 2Assistant Professor, Department of Clinical Research, Jamia Hamdard University, New Delhi, India 3 Consultant, Department of Critical Care, Max Superspeciality hospital, Phase 6, Mohali, India 4Department of Pharmacology, Adesh Institute of Medical Sciences, Bathinda,India, India