Anup B. Thakar, IPGT&RA, Gujarat Ayurved University, Jamnagar
Anup Gupta, Assistant Professor, Department of General Medicine, ICARE Institute of Medical Sciences and Research & Dr. Bidhan Chandra Roy Hospital, Haldia
Anup Marar, Medical Director, Orange City Hospital & Research Institute, Nagpur.
Anup Thakar, IPGT & RA, GAU, Jamnagar
Anusha Ch, Assistant Professor, Department Of Paediatric and Preventive Dentistry, Meghna Institute of Dental Sciences, Nizamabad.
Anusha M, Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B H Road, Tumkur, Karnataka, India
Arif Rizvi, Assistant Professor, E.I.A.H.Sc. & R, Era University, Lucknow
Arif Rizvi, Assistant Professor, E.I.A.H.Sc. & R, Era University
Arif Rizvi, Assistant Professor, Era University, Lucknow
Astik K, Arya College of Pharmacy, Jaipur, Rajasthan, India.
Aves Raza Khan, Anjuman - I - Islam’s Kalsekar Technical Campus
Ayaj S Pathan, Shivlingeshwar College of Pharmacy Almala Tq. Ausa Dist. Latur, Maharashtra India.
Ayaj S. Pathan, Shivlingeshwar College of Pharmacy Almala Tq. Ausa Dist. Latur, Maharashtra India.
Ayesha Naseer, Intern, PharmD, Aster Prime Hospital, Sultan-ul-Uloom College of Pharmacy, JNTUH, Hyderabad, Telangana, India
Ayushi Agrawal, Professor HOD & Dean – Industry Relations Acharya & BM Reddy College of Pharmacy Soldevanahalli, Acharya Post Bengaluru – 50107
Bagavad Gita, Professor & Head of the department, Department of Periodontology, Bharath Institute of Higher Education and Research, Sree Balaji Dental College and Hospitals.
Bankim Chandra Nandy, Department of Pharmaceutics, School of Pharmacy, Techno India University, Salt Lake, Kolkata, West Bengal
Beduin Mahanti, Department of Pharmaceutics, School of Pharmacy, Techno India University, Salt Lake, Kolkata, West Bengal
Benny KJ, Vinayak Mission University, Salem, Tamilnadu, India
Bhairvi K, Arya College of Pharmacy, Jaipur, Rajasthan, India.
Bhairvi Kumari, Arya College of Pharmacy, Jaipur, Rajasthan
Bharathi D R, Dept of Pharmaceutics, SJM College of Pharmacy, Chitradurga, India
Bhaskar Kuwar , Background and aims: During general anaesthesia, maneuver of laryngoscopy and tracheal intubation is accompanied by varying degree of sympathetic stimulation. This may prove detrimental in patients with compromised cardiac and cerebrovascular reserve and hence many approaches have been tried to prevent the potentially adverse circulatory responses. In the present study, we compared dexmedetomidine with labetalol to assess and evaluate the haemodynamic responses to laryngoscopy and endotracheal intubation during induction of general anaesthesia and during extubation. Material and methods: This study was carried out in ninety patients who were posted for various surgeries requiring general anaesthesia with orotracheal intubation. They were allocated into three groups. Group D patients received 0.5mcg/kg dexmedetomidine, diluted to 5ml of 0.9% normal saline, group L received 0.25mg/kg labetalol diluted to 5 ml normal saline and group C received 5ml 0.9%normal saline. All study drugs were administered over 5 minutes followed by induction with IV Propofol 2mg/kg and suxamethonium 1.5 mg/kg. Haemodynamic monitoring of systolic and diastolic blood pressure, heart rate(HR), mean arterial pressure(MAP) were done Results: Group D and group L showed statistically significant fall in HR,SBP, DBP, MAP RPP at induction, at intubation(I0), I1, I3, I5, I10, I15 than group C(p<0.001). There were decrease in HR, SBP, RPP in group D than in group L (p<0.001), while at I10 and I15 fall in MAP was significant in group D(p<0.001). Group C showed incidence of tachycardia and hypertension to be 83% and 77% respectively. Group D showed bradycardia in three patients and hypotension in four out of thirty patients which were statistically insignificant when compared to group L.(p>0.05). Conclusion: The haemodynamic responses to laryngoscopy, endotracheal intubation and extubation are better controlled with dexmedetomidine than labetalol. Keywords: Laryngoscopy, Endotracheal intubation, Haemodynamic responses, Dexmedetomidine, Labetalol.
Bhawani Prasad Bag, Assistant Professor, Department of Biotechnology & Bioinformatics, Sambalpur Univerisity, Jyoti Vihar, Burla 768019, Odisha, India
Bhushan Kamble, MBBS, MD, Assistant Professor, Department of Community Medicine, North DMC medical college & Hindu Rao Hospital, Delhi, India.

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